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1

Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) as a targeted cancer immunotherapy

Diane Seimetz, Horst Lindhofer, Carsten Bokemeyer

Journal:

Cancer Treatment Reviews

Year:

2010

Language:

english

File:

PDF, 543 KB

english, 2010

2

Gene therapy of B-cell lymphoma with cytokine gene-modified trioma cells

John Strehl, Michael Selmayr, Jean-P. Kremer, Lothar Hültner, Horst Lindhofer, Ralph Mocikat

Journal:

International Journal of Cancer

Year:

1999

Language:

english

File:

PDF, 177 KB

english, 1999

3

Immunosuppression by Fc region-mismatched anti-T cell antibody treatment

Stefan Thierfelder, Ralph Mocikat, Josef Mysliwietz, Horst Lindhofer, Elisabeth Kremmer

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 644 KB

english, 1995

4

Two new trifunctional antibodies for the therapy of human malignant melanoma

Peter Ruf, Michael Jäger, Joachim Ellwart, Susanne Wosch, Elisabeth Kusterer, Horst Lindhofer

Journal:

International Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 197 KB

english, 2004

5

Immunotherapy of malignant ascites with trifunctional antibodies

Markus M. Heiss, Michael A. Ströhlein, Michael Jäger, Rainer Kimmig, Alexander Burges, Alexandra Schoberth, Karl-Walter Jauch, Friedrich-Wilhelm Schildberg, Horst Lindhofer

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 580 KB

english, 2005

6

Bi20 (fBTA05), a novel trifunctional bispecific antibody (anti-CD20 × anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels

Michael Stanglmaier, Margot Faltin, Peter Ruf, Annette Bodenhausen, Petra Schröder, Horst Lindhofer

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

7

Humoral response to catumaxomab correlates with clinical outcome: Results of the pivotal phase II/III study in patients with malignant ascites

Marion G. Ott, Frederik Marmé, Gerhard Moldenhauer, Horst Lindhofer, Michael Hennig, Rolf Spannagl, Mirko M. Essing, Rolf Linke, Diane Seimetz

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 893 KB

english, 2012

8

Idiotype vaccination against B cell lymphoma requires injection of gene-modified tumor cells

M. Selmayr, H. Lindhofer, S. Thierfelder, R. Mocikat

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 344 KB

english, 1997

9

Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM

Martin Sebastian, Bernward Passlick, Hilke Friccius-Quecke, Michael Jäger, Horst Lindhofer, Frank Kanniess, Rainer Wiewrodt, Eckhard Thiel, Roland Buhl, Alexander Schmittel

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 331 KB

english, 2007

10

Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies

Vera Timm, Patrick Gruber, Michael Wasiliu, Horst Lindhofer, Dirk Chelius

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 694 KB

english, 2010

11

Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients

Peter Ruf, Michael Kluge, Michael Jäger, Alexander Burges, Constantin Volovat, Markus Maria Heiss, Jürgen Hess, Pauline Wimberger, Birgit Brandt, Horst Lindhofer

Journal:

British Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

12

Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 × anti-CD20 antibody and donor lymphocyte infusion

Buhmann, R, Simoes, B, Stanglmaier, M, Yang, T, Faltin, M, Bund, D, Lindhofer, H, Kolb, H-J

Journal:

Bone Marrow Transplantation

Year:

2008

Language:

english

File:

PDF, 278 KB

english, 2008

13

Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer

Ruf, P, Gires, O, Jäger, M, Fellinger, K, Atz, J, Lindhofer, H

Journal:

British Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

14

In VivoProcessing of Pr160gag-polfrom Human Immunodeficiency Virus Type 1 (HIV) in Acutely Infected, Cultured Human T-Lymphocytes

HORST LINDHOFER, KLAUS VON DER HELM, HANS NITSCHKO

Journal:

Year:

1995

Language:

english

File:

PDF, 111 KB

english, 1995

15

First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report

Klaus Pietzner, Michael Jäger, Alexandra Schoberth, Gülten Oskay-Özcelik, Marc Kuhberg, Horst Lindhofer, Jalid Sehouli

Journal:

Medical Oncology

Year:

2012

Language:

english

File:

PDF, 326 KB

english, 2012

16

Induction of long-lasting antitumor immunity by concomitant cell therapy with allogeneic lymphocytes and trifunctional bispecific antibody

Shoshana Morecki, Horst Lindhofer, Elena Yacovlev, Yael Gelfand, Peter Ruf, Shimon Slavin

Journal:

Experimental Hematology

Year:

2008

Language:

english

File:

PDF, 268 KB

english, 2008

17

Intraperitoneal immunotherapy with trifunctional antibodies: a new concept for treatment of peritoneal carcinomatosis in patients with GI-tract cancer

Michael A. Stroehlein, Uwe Gruetzner, Anwar Tarabichi, Michael Jaeger, Horst Lindhofer, Karl-Walter Jauch, Markus Heiss

Journal:

Journal of the American College of Surgeons

Year:

2005

Language:

english

File:

PDF, 47 KB

english, 2005

18

Immunotherapy medicaments containing antibodies which specifically detect the MHCII antigen of a patient to be treated

H Lindhofer, S Thierfelder

Journal:

Year:

1997

Language:

english

File:

PDF, 145 KB

english, 1997

19

Induction of a long-lasting anti-tumor immunity by a trifunctional bispecific antibody

P. Ruf, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 70 KB

english, 2001

20

Trifunctional bispecific antibody treatment of ascites due to ovarian cancer: a phase I/II study

R. Kimmig, B. Schmalfeldt, A. Burges, S. Braun, M. Jäger, M.A. Ströhlein, B. Wimberger, M. Kiechle, M.M. Heiss, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

21

A new class of trifunctional bispecific antibodies mediated efficient immunological purging of peripheral blood stem cells

A. Schoberth, N.S. Prang, H. Menzel, W. Janni, S. Braun, C. Salat, M. Heiss, H-J. Kolb, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

22

Induction of a long-lasting anti-tumor immunity by a trifunctional bispecific antibody

P. Ruf, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

23

Trifunctional bispecific antibody BiLu induces long-lasting anti-tumor immunity

P. Ruf, S. Wosch, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

24

Lysis of prostate carcinoma cells by bispecific antibodies (αEpCAM × αCD3) — visualization by a video incubation system

A. Buchner, R. Riesenberg, W. Feicht, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

25

Induction of specific anti-tumor immunity in advanced gastric cancer patients by bispecific trifunctional antibodies

M.A. Ströhlein, M. Jäger, H. Lindhofer, F.W. Schildberg, M.M. Heiss

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

26

Immune monitoring of tumor cell elimination from malignant ascites during immunotherapy with trifunctional bispecific antibodies

M. Jäger, M.A. Ströhlein, S. Anton, N.S. Prang, S. Schoberth, M.M. Heiss, A. Burges, R. Kimmig, F.W. Schildberg, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

27

A trifunctional bispecific antibody Bi20 (CD20xCD3) efficiently kills B-cell lymphoma cells by unstimulated peripheral blood mononuclear cells (PBMC)

M. Faltin, P. Ruf, E. Kusterer, T. Grob, H. Lindhofer

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

28

Pilotstudy with a trifunctional bispecific antibody in patients with head and neck cancer

B. Wollenberg, M. Andratschke, C. Pauli, H. Ledderose, H. Lindhofer, R. Zeidler

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 56 KB

english, 2001

29

A bispecific antibody induces efficient killing of tumor cells

R. Zeidler, G. Reisbach, S. Lang, B. Wollenberg, B. Schmitt, S. Erndl, S. Chaubal, H. Lindhofer

Journal:

European Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 145 KB

english, 1997

30

1312 Catumaxomab therapy eliminates putative CD133+ EpCAM+ cancer stem celles from malignant ascites: data from a pivotal phase II/III study

H. Lindhofer, A. Schoberth, D. Pelster, J. Hess, J. Herold, M. Jäger

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

31

1313 Catumaxomab treatment reduces VEGF protein levels within malignant ascites: data from a pivotal phase II/III study

M. Jäger, A. Schoberth, B. Theissen, J. Hess, H. Friccius, H. Lindhofer

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 68 KB

english, 2009

32

Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model

Peter Ruf, Beatrix Schäfer, Nina Eissler, Ralph Mocikat, Juergen Hess, Matthias Plöscher, Susanne Wosch, Ivonne Suckstorff, Christine Zehetmeier, Horst Lindhofer

Journal:

Journal of Translational Medicine

Year:

2012

Language:

english

File:

PDF, 390 KB

english, 2012

33

Cancer therapy with trifunctional antibodies: linking innate and adaptive immunity

Hess, Juergen, Ruf, Peter, Lindhofer, Horst

Journal:

Future Oncology

Year:

2012

Language:

english

File:

PDF, 733 KB

english, 2012

34

THE MEAT OF THE PEOPLE.

Braicu, I., Atz, J., Dettmar, K., Martinius, H., Spannagl, R., Seimetz, D., Lindhofer, H., Chekerov, R., Pietzner, K., Sehouli, J.

Journal:

Year:

1906

Language:

english

File:

PDF, 177 KB

english, 1906

35

LEEDS.

Braicu, I., Atz, J., Dettmar, K., Martinius, H., Spannagl, R., Seimetz, D., Lindhofer, H., Chekerov, R., Pietzner, K., Sehouli, J.

Journal:

Year:

1911

Language:

english

File:

PDF, 204 KB

english, 1911

36

8007 ORAL Catumaxomab Induces Efficient Anti-tumour Activity in Vitro With Immune Cells From Ovarian Cancer Patients After Chemotherapy Treatment

Braicu, I., Atz, J., Dettmar, K., Martinius, H., Spannagl, R., Seimetz, D., Lindhofer, H., Chekerov, R., Pietzner, K., Sehouli, J.

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 40 KB

english, 2011

37

6507 Catumaxomab treatment in gastric-cancer patients with malignant ascites – subgroup-analysis of a pivotal trial

Heiss, M., Linke, R., Friccius-Quecke, H., Klein, A., Hennig, M., Lindhofer, H., Parsons, S.

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 47 KB

english, 2009

38

Immunomonitoring Results of a Phase II/III Study of Malignant Ascites Patients Treated with the Trifunctional Antibody Catumaxomab (Anti-EpCAM x Anti-CD3)

Jager, M., Schoberth, A., Ruf, P., Hess, J., Hennig, M., Schmalfeldt, B., Wimberger, P., Strohlein, M., Theissen, B., Heiss, M. M., Lindhofer, H.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 342 KB

english, 2012

39

The Role of Relative Lymphocyte Count as a Biomarker for the Effect of Catumaxomab on Survival in Malignant Ascites Patients: Results from a Phase II/III Study

Heiss, M. M., Strohlein, M. A., Bokemeyer, C., Arnold, D., Parsons, S. L., Seimetz, D., Lindhofer, H., Schulze, E., Hennig, M.

Journal:

Clinical Cancer Research

Year:

2014

Language:

english

File:

PDF, 475 KB

english, 2014

40

EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges

Chaudry, M A, Sales, K, Ruf, P, Lindhofer, H, Winslet, M C

Journal:

British Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 195 KB

english, 2007

41

Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies

Schuster, Friedhelm R., Stanglmaier, Michael, Woessmann, Wilhelm, Winkler, Beate, Siepermann, Meinolf, Meisel, Roland, Schlegel, Paul G., Hess, Jürgen, Lindhofer, Horst, Borkhardt, Arndt, Buhmann, Ray

Journal:

British Journal of Haematology

Year:

2015

Language:

english

File:

PDF, 990 KB

english, 2015

42

Trifunctional Bispecific Antibodies Induce Tumor-Specific T Cells and Elicit a Vaccination Effect

Eissler, N., Ruf, P., Mysliwietz, J., Lindhofer, H., Mocikat, R.

Journal:

Cancer Research

Year:

2012

Language:

english

File:

PDF, 845 KB

english, 2012

43

The Trifunctional Antibody Ertumaxomab Destroys Tumor Cells That Express Low Levels of Human Epidermal Growth Factor Receptor 2

Jager, M., Schoberth, A., Ruf, P., Hess, J., Lindhofer, H.

Journal:

Cancer Research

Year:

2009

Language:

english

File:

PDF, 494 KB

english, 2009

44

Lysis of Prostate Carcinoma Cells by Trifunctional Bispecific Antibodies ( EpCAM x CD3)

Riesenberg, R., Buchner, A., Pohla, H., Lindhofer, H.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

45

Long-Term Treatment of HIV-Infected MT-4 Cells in Culture with HIV Proteinase Inhibitor RO 31-8959 Leads to Complete Cure of Infection

Nitschko, H., Lindhofer, H., Schatzl, H., Eberle, J., Deby, G., Kranz, B., von der Helm, K.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

1994

Language:

english

File:

PDF, 460 KB

english, 1994

46

Immunotherapy of Peritoneal Carcinomatosis with the Antibody Catumaxomab in Colon, Gastric, or Pancreatic Cancer: An Open-Label, Multicenter, Phase I/II Trial

Ströhlein, Michael A., Lordick, Florian, Rüttinger, Dominik, Grützner, Klaus-Uwe, Schemanski, Oliver C., Jäger, Michael, Lindhofer, Horst, Hennig, Michael, Jauch, Karl-Walter, Peschel, Christian, Heis

Journal:

Year:

2011

File:

PDF, 341 KB

2011

47

Increased chondroitin sulphate proteoglycan expression (B5 immunoreactivity) in metastases of uveal melanoma

Kiewe, P, Bechrakis, N., Schmittel, A, Ruf, P, Lindhofer, H, Thiel, E, Nagorsen, D

Journal:

Annals of Oncology

Year:

2006

Language:

english

File:

PDF, 378 KB

english, 2006

48

Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery

Deppisch, N., Ruf, P., Eissler, N., Neff, F., Buhmann, R., Lindhofer, H., Mocikat, R.

Journal:

Molecular Cancer Therapeutics

Year:

2015

Language:

english

File:

PDF, 710 KB

english, 2015

49

Structural and functional characterization of the trifunctional antibody catumaxomab

Chelius, Dirk, Ruf, Peter, Gruber, Patrick, Plöscher, Matthias, Liedtke, Reinhard, Gansberger, Eva, Hess, Juergen, Wasiliu, Michael, Lindhofer, Horst

Journal:

Year:

2010

Language:

english

File:

PDF, 1.12 MB

english, 2010

50

Expression of Epithelial Cell Adhesion Molecule in Paired Tumor Samples of Patients With Primary and Recurrent Serous Ovarian Cancer

Pietzner, Klaus, Woopen, Hannah, Richter, Rolf, Joens, Thomas, Braicu, Elena Ioana, Dimitrova, Desislava, Mellstedt, Håkan, Darb-Esfahani, Silvia, Denkert, Carsten, Lindhofer, Horst, Fotopoulou, Chris

Journal:

International Journal of Gynecological Cancer

Year:

2013

Language:

english

File:

PDF, 868 KB

english, 2013

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